FUTURE LOOKS HEALTHY FOR LIFFORD HOSPITAL AFTER MAJOR REFURBISHMENT

first_imgCatering staff/Multi task staff from L to RMaureen Doherty ,Yvonne Mc Ginley ,Noeleen CattersonTwo years ago it was on the verge of closure until a campaign by local people kept Lifford Community Hospital open.Now the future of the 20 bed facility looks very positive after substantial refurbishment works which includes a new kitchen were carried out.The work was carried out by Joseph Mc Menamin & Sons from Stranorlar. The kitchen works included new hygienic wall and floor finishes, electrical works and a catering equipment upgrade.This will result in streamlining the work of the catering department, increasing efficiency and will improve overall delivery of this service.Lifford hospital provides catering for 20 residents, a day centre which is off site, a meals on wheel service to the local community.It also caters to residents of the Habinteg Housing Association and staff of Lifford hospital. Lifford Community HospitalThe kitchen was upgraded to the highest of standards in conjunction with Aoife Gardiner, Senior Environmental Health Officer with the HSE and the Environmental Health Department, Tony Kitterick, HSE Estates Department and Brendan McGowan Catering Manger for the region.All of the works were approved by John Hayes, Area Manger for Donegal, and Gwen Mooney Service Manager Older people services.Gwen stated that the Catering Department is ‘finished to a very high standard and complies with all food safety standards, Health and Safety and HIQA requirements’. FUTURE LOOKS HEALTHY FOR LIFFORD HOSPITAL AFTER MAJOR REFURBISHMENT was last modified: October 3rd, 2014 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:donegalHSELifford Community Hos[italnew kitchenlast_img read more

Cell Quality Control Runs a Tight Ship

first_imgWithout the surveillance and rapid response of quality control, cells would collapse and die.  Here are some recently-published examples of nanoheroes in action.Plant checkpoints:  Picture a child watching the wonder of a seedling breaking through the soil into the light for the first time.  Within hours, the ghostly-white stem turns green, and a day later, leaves begin to appear.  Does he or she have any idea what is going on at a scale too small to see?  Not until that kid grows into a modern lab scientist with sophisticated equipment.  The transformation requires the coordinated transportation of key elements through specialized checkpoints, an international team reported in PNAS.1    Without boring the reader with technical terms, what basically happens is this.  The underground seedling contains pre-chloroplast parts in readiness for the arrival into sunlight, but saves its energy by not allowing the light-gathering factories to assemble until it’s time.  “Chloroplasts need to import a large number of proteins from the cytosol because most are encoded in the nucleus,” they reported.  Once there, they have a double membrane to get through.  Specialized gates permit entry of the authenticated parts.  One particular light-sensitive part has its own unique gate.  The team decided to see what happened when they mutated one gene in the process.  The results were not pretty: the light-sensitive molecules accumulated outside the plastid because they couldn’t get into the factory.  “After a dark-to-light shift, this pigment operated as photosensitizer and caused rapid bleaching and cell death,” they found.  “Our results underscore the essential role of the substrate-dependent import pathway” that this protein depends on.  Maybe this error resembles a chemical spill outside a pharmaceutical plant, or pistons firing before they get into the engine.Now hear this:  In a surprise finding that might provide hope for the deaf, scientists publishing in PNAS reported that “Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness.”2  Two protein partners are needed for healthy hair-cell formation in the cochlea of the inner ear.  Mutations in one of them, connexin26, account for about half of all cases of inherited human deafness.  Usually, connexin26 and connexin30 join together to form gap junctions, but if one is mutated, deafness results.  The gap junctions are essential for cell-to-cell communication.  Surprisingly, connexin26 (Cx26) appears able to bridge the gap when connexin30 (Cx30) is missing; therefore, “up-regulation of Cx26 or slowing down its protein degradation might be a therapeutic strategy to prevent and treat deafness caused by Cx30 mutations.”    The scientists suspected that these two isoforms of connexins regulate each other.  They also noted that this partnering occurs in the lens of the eye.  Losing one by mutation, therefore, affects the regulation of the partner.  On a hunch that one of the isoforms could compensate for the loss of the other if allowed to assemble, and could build functional gap junctions on its own, they tried up-regulating the remaining connexin.  To their surprise, hearing was completely restored in mice. Bad translator triggers SOS:  We’ve talked about the DNA translation team a number of times (e.g., 12/28/2006, 07/26/2005, 06/09/2003, 04/29/2003).  The team of 20 aminoacyl-tRNA synthetases, as they are called, have rigid requirements.  “Mistranslation in bacterial and mammalian cells leads to production of statistical proteins that are, in turn, associated with specific cell or animal pathologies, including death of bacterial cells, apoptosis of mammalian cells in culture, and neurodegeneration in the mouse,” said Bacher and Schimmel in PNAS.3  “A major source of mistranslation comes from heritable defects in the editing activities of aminoacyl-tRNA synthetases.”  This is because the protein machines, which snap the right amino acid onto the appropriate transfer-RNA (tRNA), cannot perform their vital role in protein synthesis if broken.    These researchers suspected that broken synthetases could also cause mutations.  They decided to test what happens when they caused an “editing defect” in one of them.  (These enzymes are usually able to proofread their own errors with a high degree of accuracy.)  The result, again, was not pretty: “A striking, statistically significant, enhancement of the mutation rate in aging bacteria was found.”  The bug was like flipping a fire alarm: “This enhancement comes from an increase in error-prone DNA repair through induction of the bacterial SOS response,” they explained.  “Thus, mistranslation, as caused by an editing-defective tRNA synthetase, can lead to heritable genetic changes that could, in principle, be linked to disease.”    Another press release from Ohio State also discussed the neurological disease that can result from mistranslated proteins caused by mutated aminoacyl-tRNA synthetases. 1Pollman et al, “A plant porphyria related to defects in plastid import of protochlorophyllide oxidoreductase A,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0610934104, published online before print January 29, 2007.2Ahmad et al, “Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0606855104, published online before print January 16, 2007.3Jamie M. Bacher and Paul Schimmel, “An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response,” Proceedings of the National Academy of Sciences USA, 10.1073/pnas.0610835104, published online before print January 30, 2007.Dear Darwinist, does this increase your faith that random accidents in working systems are going to make things better?  Is this a better way to build a plant, an ear, or a translation system?  If you think terrorism is the best way to build a civilization, reread the 12/14/2006 entry. (Visited 8 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

‘Last-mile’ fibre network for businesses

first_img22 April 2010South African mobile provider Vodacom has launched its Metro-Ethernet network, a super-fast “last mile” fibre-optic connection offering businesses in the country’s metropolitan areas cost-effective, scalable, reliable bandwidth.Dubbed “Metro E”, the new fibre-optic network offers South African companies service speed options from 2Mbps to 1Gbps, control over how much bandwidth they need, and flexibility as to when they need it.The network allows for easy, rapid transfer of large amounts of data and is ideal for services that require smooth data provisioning, such as video conferencing.“Companies are facing increasing bandwidth requirements as they deploy more high-bandwidth applications, such as voice, video and networked storage,” Vodacom Business managing executive Ermano Quartero said in a statement this week.“But in order to deploy these applications, companies need a high-bandwidth, low-cost, reliable last-mile service. Vodacom Business is able to now meet these needs with its Metro E service.”According to Quartero, Metro E is targeted at the enterprise and large business markets, which require high-speed and reliable transmission links supported by stringent service-level agreements.Wide Area NetworkMetro E will connect businesses to a wide area network, such as the internet, and enable large companies to use the Metro E network to connect branch offices to mission-critical applications, as well as linking offices in different metropolitan areas.It is based on Vodacom’s extensive, high-capacity optical fibre infrastructure, which is centred on Vodacom Business’ Service Hubs in Johannesburg, Pretoria, Cape Town and Durban.The promised benefits of Metro E network include super-fast connections, evenly matched upload and download speeds, the option to buy data in increments of 2Mbps, easy one-device installation, and efficient service.Quality of serviceThe Metro E fibre network has been laid along the routes of large businesses, which makes for easy access to the Vodacom Business fibre termination point – only 50 to 100 metres from their premises.“Metro E provides companies with more control over their information and communications infrastructure, supported by the latest optic fibre solution. And as Vodacom Business owns the last mile, there is no need for third-party suppliers – ensuring a guaranteed, managed quality of service.”Metro E is available immediately to all businesses based in South Africa’s major metropolitan areas.SAinfo reporterWould you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more